Hidetaka Hara Selected Research

Heterologous Transplantation (Xenotransplantation)

10/2022	Will previous palliative surgery for congenital heart disease be detrimental to subsequent pig heart xenotransplantation?
1/2021	The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure.
1/2021	A perspective on the potential detrimental role of inflammation in pig orthotopic heart xenotransplantation.
1/2021	Immunological selection and monitoring of patients undergoing pig kidney transplantation.
1/2021	Pig kidney xenotransplantation: Progress toward clinical trials.
11/2020	The immune system in infants: Relevance to xenotransplantation.
10/2019	Indicators of impending pig kidney and heart xenograft failure: Relevance to clinical organ xenotransplantation - Review article.
2/2019	The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?
1/2019	Evidence for the important role of inflammation in xenotransplantation.
1/2019	The complex functioning of the complement system in xenotransplantation.

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Hidetaka Hara Research Topics

Disease

14	Inflammation (Inflammations) 01/2021 - 01/2015
9	Thrombocytopenia (Thrombopenia) 01/2022 - 01/2012
5	Infections 01/2021 - 01/2017
4	Congenital Heart Defects (Congenital Heart Defect) 10/2022 - 02/2019
4	Thrombotic Microangiopathies 07/2017 - 03/2009
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 01/2017
2	Hypoplastic Left Heart Syndrome 11/2020 - 02/2019
2	Thrombosis (Thrombus) 10/2019 - 07/2012
2	Wounds and Injuries (Trauma) 10/2017 - 10/2017
2	Blindness (Hysterical Blindness) 11/2015 - 03/2014
2	Corneal Diseases (Corneal Disease) 05/2014 - 03/2014
1	Cytokine Release Syndrome 07/2022
1	Sickle Cell Anemia (Hemoglobin S Disease) 11/2021
1	Hypovolemia 01/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	Anemia 01/2021
1	Corneal Opacity 11/2019
1	Vasculitis (Vasculitides) 10/2019
1	Reperfusion Injury 01/2019
1	Lung Diseases (Lung Disease) 12/2018
1	Burns 11/2018
1	Edema (Dropsy) 01/2017
1	Kidney Diseases (Kidney Disease) 08/2016
1	Brain Death (Brain Dead) 01/2016
1	Disease Progression 01/2016
1	Keratoconus 03/2014
1	Fuchs' Endothelial Dystrophy 03/2014
1	Multiple Myeloma 11/2013
1	Rubella (German Measles) 08/2013
1	Mumps 08/2013
1	Measles 08/2013
1	Human Influenza (Influenza) 08/2013
1	Typhoid Fever (Typhoid) 08/2013
1	Hypertrophy 01/2012
1	Necrosis 01/2012
1	Hemorrhage 01/2012
1	Pathologic Constriction (Stenosis) 07/2005
1	Ischemia 11/2004
1	Exanthema (Rash) 07/2004
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 07/2004
1	Graft vs Host Disease (Graft-Versus-Host Disease) 07/2004
1	Pancytopenia 07/2004
1	Fever (Fevers) 07/2004

Drug/Important Bio-Agent (IBA)

5	Fibrinogen (Factor I)FDA Link 10/2019 - 05/2015
4	Interleukin-6 (Interleukin 6)IBA 07/2022 - 01/2017
3	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2022 - 01/2019
3	AntibodiesIBA 11/2020 - 07/2012
3	Proteins (Proteins, Gene)FDA Link 01/2017 - 07/2015
2	AntigensIBA 11/2020 - 07/2012
2	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020 - 11/2013
2	Interleukin-17 (Interleukin 17)IBA 01/2017 - 01/2017
1	Etanercept (Enbrel)FDA Link 01/2021
1	CarbohydratesIBA 11/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020
1	InterleukinsIBA 01/2020
1	Complement System Proteins (Complement)IBA 01/2019
1	ChemokinesIBA 01/2018
1	CollagenIBA 10/2017
1	Prion ProteinsIBA 10/2017
1	Delayed-Action PreparationsIBA 10/2017
1	Histones (Histone)IBA 10/2017
1	CytokinesIBA 01/2017
1	Y 27632IBA 10/2016
1	rho-Associated KinasesIBA 10/2016
1	MicroRNAs (MicroRNA)IBA 08/2016
1	Biomarkers (Surrogate Marker)IBA 08/2016
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2016
1	O-(glucuronic acid 2- sulfate)- (1- - 4)- O- (2,5)- anhydromannitol 6-sulfateIBA 01/2016
1	Insulin (Novolin)FDA Link 01/2016
1	Blood Glucose (Blood Sugar)IBA 01/2016
1	fibrin fragment D (D-dimer)IBA 09/2015
1	C-Reactive ProteinIBA 09/2015
1	Bortezomib (Velcade)FDA Link 11/2013
1	Proteasome InhibitorsIBA 11/2013
1	HLA Antigens (Human Leukocyte Antigens)IBA 11/2013
1	Immunoglobulin G (IgG)IBA 08/2013
1	Thrombin FDA Link 08/2012
1	Abatacept (Orencia)FDA Link 07/2012
1	FibrinIBA 01/2012

Therapy/Procedure

19	Heterologous Transplantation (Xenotransplantation) 10/2022 - 08/2012
10	Transplantation 01/2021 - 07/2004
4	Therapeutics 01/2021 - 10/2016
3	Heart Transplantation (Grafting, Heart) 01/2022 - 09/2015
3	Corneal Transplantation (Keratoplasty) 11/2019 - 03/2014
3	Liver Transplantation 08/2012 - 07/2004
2	Euthanasia (Mercy Killing) 12/2018 - 01/2012
2	Organ Transplantation 11/2013 - 03/2009
1	Palliative Care (Palliative Therapy) 10/2022
1	Blood Transfusion (Blood Transfusions) 11/2021
1	Glycemic Control 01/2021
1	Islets of Langerhans Transplantation 01/2021
1	Lung Transplantation 12/2018
1	Kidney Transplantation 12/2018
1	Slit Lamp 01/2017
1	Operative Surgical Procedures 01/2016
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2016
1	Plasma Exchange 11/2013
1	Sutures (Suture) 07/2005